Do TUNEL and Other Apoptosis Assays Detect Cell Death in Preclinical Studies?
نویسندگان
چکیده
منابع مشابه
Correlation of micronucleus and apoptosis assays with reproductive cell death.
The relationship between ionizing radiation-induced cell killing and DNA damage measured by the micronucleus and apoptosis assays was determined in three established cell lines (L929, HL-60, and Chang). Irradiation experiments revealed a dose-dependent increase of micronucleated cells until a certain dose was reached. Above this dose no further increase of the micronucleus frequency was observe...
متن کاملDistinguishing between apoptosis, necrosis, necroptosis and other cell death modalities.
This issue of Methods contains a series of articles that cover the major techniques used to measure apoptosis, necrosis and variations thereof, at the population, single cell, organelle and molecular level. Although we used to think of apoptosis as programmed or regulated cell death and necrosis as strictly non-programmed or unregulated cell death [1,2], data have emerged in recent years which ...
متن کاملApoptosis: mode of cell death induced in T cell leukemia lines by dexamethasone and other agents.
Glucocorticoids can mediate the destruction of thymocytes and T cell-derived leukemia cells through a mechanism known as apoptosis. The characteristic feature of apoptosis is fragmentation of DNA at internucleosomal linkers through the activity of a specific endonuclease. In this study, an attempt was made to compare dexamethasone-induced apoptosis in two T cell-derived human leukemia lines (CE...
متن کاملApoptosis, Cell Death and Inflammation
ceptors (e.g. members of the TNF superfamily such as TNFR1, CD95 or Toll-like receptors [4] ), or the intracellular sensors, nucleotide-binding and oligomerization domain (NOD)-like receptors [5, 6] , all of which can instigate inflammatory responses and modulate the cell’s survival/death balance. NOD-like receptors can assemble into large multiprotein complexes, termed inflammasomes, which can...
متن کاملApoptosis, cell death and inflammation.
ceptors (e.g. members of the TNF superfamily such as TNFR1, CD95 or Toll-like receptors [4] ), or the intracellular sensors, nucleotide-binding and oligomerization domain (NOD)-like receptors [5, 6] , all of which can instigate inflammatory responses and modulate the cell’s survival/death balance. NOD-like receptors can assemble into large multiprotein complexes, termed inflammasomes, which can...
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ژورنال
عنوان ژورنال: International Journal of Molecular Sciences
سال: 2020
ISSN: 1422-0067
DOI: 10.3390/ijms21239090